Basic Information
VIS ID
TVIS44014897
Fusion event
HTLV-1-MAP3K7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
91283705/90573986 (Hg38)
End
91283705/90573986 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6G
Target gene
MAP3K7
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-1226-5p ; hsa-mir-16-5p ; hsa-mir-143-3p ; hsa-mir-4635 ; hsa-mir-4709-3p ; hsa-mir-3914 ; hsa-mir-548au-3p ; hsa-mir-107 ; hsa-mir-545-3p ; hsa-mir-1295b-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-599 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-5589-3p ; hsa-mir-875-5p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-3671 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-892b
Nearest miRNA
hsa-mir-10398/Upstream/261153; hsa-mir-1202/Downstream/947674;
Nearest TSS
ENST00000381078/Upstream/20522; ENST00000452624/Downstream/12897;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/276761, chr6-CpG: 64/Downstream/12653
Nearest cancer related gene
MAP3K7(OG, No orient, 0)
Upstream sequence
GCACTCAGTGTTCTGTGGTTTAGGTTCTTGTTCTCCTTCACAATTCTCATCAGACATTTGTACTTGCCATTCAGTTACTTTATTGTGAATAGAGGGTACT
Downstream sequence
GGCTACCTGGTACCATTAGAATAAATgaaagagcacacccaggctctgaaatccaacagacttgagtttgaatgtagggctctgtctacctattatctct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate