Basic Information
VIS ID
TVIS44014902
Fusion event
HTLV-1-ABCB5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
20702503/20662880 (Hg38)
End
20702503/20662880 (Hg38)
Orient
-
Location type
Intronic
Target gene
ABCB5
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-4480 ; hsa-mir-192-3p ; hsa-mir-330-3p ; hsa-mir-100-3p ; hsa-mir-4311 ; hsa-mir-4676-5p ; hsa-mir-607 ; hsa-mir-7855-5p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-5571-3p ; hsa-mir-3671 ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-4284 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6890-3p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-580-5p ; hsa-mir-522-5p
Nearest miRNA
hsa-mir-1302-6/Upstream/957444; hsa-mir-10399/Downstream/808178;
Nearest TSS
ENST00000635602/Upstream/15458; ENST00000441315/Downstream/60214;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/330999, chr7-CpG: 21/Downstream/113739
Upstream sequence
cctttgatagatcagggcccctttgagaatctgattgagaaagggaaaaataaaccaccataactctttagagaagtatacaaattcacttatacaaaaa
Downstream sequence
gacttacacgtactcttgagggagtcatagacccccgaagccatttgtgggtccTTATTTTAGATGTAACAAAGGAACAAatggatgataacagctaatc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate