Basic Information
VIS ID
TVIS44014915
Fusion event
HTLV-1-XKR9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
71729119/70816884 (Hg38)
End
71729119/70816884 (Hg38)
Orient
+
Location type
Intronic
Target gene
XKR9
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-7156-3p ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-1272 ; hsa-mir-8084 ; hsa-mir-3662 ; hsa-mir-3121-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-548l ; hsa-mir-1277-5p ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-6505-5p ; hsa-mir-4789-5p ; hsa-mir-7153-3p
Nearest miRNA
hsa-mir-124-1/Upstream/6437627; hsa-mir-10400/Downstream/3731659;
Nearest TSS
ENST00000518652/Upstream/146311; ENST00000521084/Downstream/338573;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/147469, chr8-CpG: 99/Downstream/730445
Nearby gene
XKR9(+80942) ;
Upstream sequence
ggcttcattcctgggatgcaaggttggttcaacatgtgcaaatcaataattgtgattcaccacataaacagaattaaaaacaacaaccatatgatcatct
Downstream sequence
caatacatgcagaaaaagcttttaataaaatccacattctttaatgataaaaaccctcaaccaactgggcattgaaggaacatatctcacaataacaaga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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