Basic Information
VIS ID
TVIS44014925
Fusion event
HTLV-1-PGM5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
71139899/68524983 (Hg38)
End
71139899/68524983 (Hg38)
Orient
-
Location type
Intronic
Target gene
PGM5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-101-2/Upstream/27291148; hsa-let-7a-1/Downstream/2284992;
Nearest TSS
ENST00000422679/Upstream/28158; ENST00000413269/Downstream/15884;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/167295, chr9-CpG: 122/Downstream/179799
Upstream sequence
gtcaatcctgtgtcgcactgggctttagtgtcttcatctgtgccatgaagaaatcaaatgacaccaatccacattcctctctgcttttgaaattctgtgc
Downstream sequence
ttccaGCTCCATGTTAGAAAACTCACATCCACAGTTCATAACCCCTCTTTTTGCTCCTCATTCCAACTGCCTCTCCAATTGCCCCAGGAAAATTAACTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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