Basic Information
VIS ID
TVIS44014943
Fusion event
HTLV-1-ENDOD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
94855264/95122100 (Hg38)
End
94855264/95122100 (Hg38)
Orient
+
Location type
Intronic
Target gene
ENDOD1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-192-5p ; hsa-mir-9-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-5590-5p ; hsa-mir-4727-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-642a-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-2276-5p ; hsa-mir-4469 ; hsa-mir-6892-3p ; hsa-mir-7705 ; hsa-mir-625-3p ; hsa-mir-6505-5p ; hsa-mir-7156-3p ; hsa-mir-4789-5p ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-7153-3p ; hsa-mir-8084
Nearest miRNA
hsa-mir-10392/Upstream/655520; hsa-let-7a-2/Downstream/1219338;
Nearest TSS
ENST00000527297/Upstream/32290; ENST00000545216/Downstream/28439;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/31653, chr11-CpG: 16/Downstream/28071
Upstream sequence
TAATCCAGAAATTGCCATCTGAAATAACCTTTTACATCATAGGTTTATTTTTGTCTTTAGGGAGCAATGTTGTCAGTAATTTACTATAATTGCAATAACC
Downstream sequence
AGATCATTAAACCATGTCTGTAGAGAGCATGGAAAAATACATCTACTCTTTAAGTGACAATGTATCAAAGAATATACTAAGACTATTTTAATCAAATAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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