Basic Information
VIS ID
TVIS44014951
Fusion event
HTLV-1-FBLN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
13604766/13563266 (Hg38)
End
13604766/13563266 (Hg38)
Orient
-
Location type
Intronic
Target gene
FBLN2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4775 ; hsa-mir-32-3p ; hsa-mir-548at-5p ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-12127/Upstream/3168704; hsa-let-7g/Downstream/1932973;
Nearest TSS
ENST00000440867/Upstream/14085; ENST00000465610/Downstream/3210;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/13758, chr3-CpG: 41/Downstream/7157
Upstream sequence
ATTTTTGGACAGTTTCTAGGATCAGGCTGTCTTCCCTGCCTCTGCCTGGTGTGTGGCTGTGTGTCTGTGCTCAGTAAACTCCATGGCCActgtgggtgcc
Downstream sequence
cacccaggtctctcacctggaggtgcacatgtctcccagcggccacaggtgctggctgctgatggctcacacctgtgccttctccagctgcctgcccttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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