Basic Information
VIS ID
TVIS44014957
Fusion event
HTLV-1-RAB44 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
36685103/36717326 (Hg38)
End
36685103/36717326 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA6H
Target gene
RAB44
miRNAs that regulate target gene
hsa-mir-4535 ; hsa-mir-4776-5p ; hsa-mir-711 ; hsa-mir-6859-3p ; hsa-mir-361-3p ; hsa-mir-4691-3p ; hsa-mir-22-3p ; hsa-mir-449b-3p
Nearest miRNA
hsa-mir-1236/Upstream/94814; hsa-mir-10398/Downstream/838039;
Nearest TSS
ENST00000381078/Upstream/19516; ENST00000355190/Downstream/40055;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/32968, chr6-CpG: 147/Downstream/121779
Upstream sequence
ACCTTGTGTCTGACCCTCCCATCTCTGGCTGTCTTCCCCTCCCCAGGCAGATGGAAATCTGGCAACTGTGGGGGCAGCTGCGGCAGGAGGAGCCCCAGCT
Downstream sequence
GGCAGGCAACCTGGCAGGCTTTCTGGCCAAGATGACCAGCCGCCTGCAGGAGGCCCAGGCGGACAAGGAGGCCCTGGAGCTGACCCTGAGGAAGTGAGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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