Basic Information
VIS ID
TVIS44014961
Fusion event
HTLV-1-OPHN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q12
Reference genome
GRCh37/hg19
Start
67265818/68045976 (Hg38)
End
67265818/68045976 (Hg38)
Orient
+
Location type
UTR3
Target gene
OPHN1
miRNAs that regulate target gene
hsa-mir-548m ; hsa-mir-3187-3p ; hsa-mir-653-3p ; hsa-mir-4529-5p ; hsa-mir-6847-3p ; hsa-mir-539-5p ; hsa-mir-3185 ; hsa-mir-3190-5p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-5680 ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-551b-5p ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-7156-3p ; hsa-mir-5007-3p ; hsa-mir-1272 ; hsa-mir-8084 ; hsa-mir-3662 ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-92a-1-5p ; hsa-mir-4515 ; hsa-mir-1288-3p ; hsa-mir-4740-5p ; hsa-mir-3607-3p ; hsa-mir-1208 ; hsa-mir-7844-5p ; hsa-mir-6505-5p ; hsa-mir-4789-5p ; hsa-mir-7153-3p
Nearest miRNA
hsa-let-7f-2/Upstream/2026997; hsa-mir-105-1/Downstream/1976881;
Nearest TSS
ENST00000429181/Upstream/31075; ENST00000462972/Downstream/66446;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/499539, chrX-CpG: 27/Downstream/86832
Upstream sequence
TAATGGGGAAAAAAAACTTGCATAGGAGCCTGGGACCTGAGATCTTGTACTGGTGTGAtcactaccttgctctgcctcagttcccccgactggaaactgg
Downstream sequence
gcagttgttagactaaatgattttgaaaagcccttccaATCAAGGGCTTATATGGATTGTAAAAAGAGTATTTTACTCAAGTGCTgtggttcttgacttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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