Basic Information
VIS ID
TVIS44014963
Fusion event
HTLV-1-PRAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135163212/133349708 (Hg38)
End
135163212/133349708 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PRAP1
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-181a-5p ; hsa-mir-181c-5p
Nearest miRNA
hsa-mir-107/Upstream/102088; hsa-mir-3944/Downstream/21848;
Nearest TSS
ENST00000439456/Upstream/2340; ENST00000528127/Downstream/1018;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/12647, chr10-CpG: 117/Downstream/7433
Upstream sequence
GCCGTGGCCCCGCAGCTCTGGGACACAGCAGGTGCCCTGCCTGCAGCAGCGTGCAGCCTCAGGGCTCTGTGGGCGTGGGGCTGTGGGCCCTCGCTGCTCC
Downstream sequence
ATACCCACCCATACCCACACCCATGTGCAAGTGTGTTCATGTGTGTCCCCACGTGGAGGGCGGCACAGAGGCATGGCAGAACCTCTGGAGTTTCCAAGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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