Basic Information
VIS ID
TVIS44014964
Fusion event
HTLV-1-EXT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
44215612/44194062 (Hg38)
End
44215612/44194062 (Hg38)
Orient
-
Location type
Intronic
Target gene
EXT2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-4709-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3185 ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-4632-5p ; hsa-mir-6735-5p ; hsa-mir-4436b-3p ; hsa-mir-548p ; hsa-mir-6753-5p
Nearest miRNA
hsa-mir-129-2/Upstream/612579; hsa-let-7a-2/Downstream/1497642;
Nearest TSS
ENST00000527297/Upstream/64019; ENST00000528159/Downstream/12803;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/97618, chr11-CpG: 19/Downstream/109263
Nearest cancer related gene
EXT2(TSG, No orient, 0)
Upstream sequence
ATGAGACCCGATCTGTTGTCTTGCCAGCGACTCTGGTTCCATGTCCCTGGCAGCTCCTTGAAATCAGAGCTGCGATGCCTTTCAGGGCTGCCTCAGTTTA
Downstream sequence
AATGCCAAGGCATTCGTTTTGTGAGCCTAAGCTTTGCATCTCTTAGGGAATTTTCCTCTCTTCTTAATGTCATAAAGACATTTAAGTGTGTTGGCATTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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