Basic Information
VIS ID
TVIS44014969
Fusion event
HTLV-1-MARK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.32
Reference genome
GRCh37/hg19
Start
103964941/103498604 (Hg38)
End
103964941/103498604 (Hg38)
Orient
+
Location type
Intronic
Target gene
MARK3
miRNAs that regulate target gene
hsa-mir-331-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/958878; hsa-mir-12121/Downstream/618801;
Nearest TSS
ENST00000550708/Upstream/7065; ENST00000555235/Downstream/261;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/112233, chr14-CpG: 322/Downstream/22122
Upstream sequence
CATGTCATTCAGGTTTATCAAAAGGTAGGATTTATATATACACATTTATTTTTCAATCCTCACTCCCAAATGGCTCCTGCAATTAACATTAGGTTTGGCT
Downstream sequence
TTCTGGCCCTGTTTTTTCCTTATAAACTAAACTTTCTGCTGATAACTAAATACTTAATTCCTTGAAAGGAAATTGAAAAGAAATAGATTAACTCTGTCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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