Basic Information
VIS ID
TVIS44014972
Fusion event
HTLV-1-CLTC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
57699200/59621839 (Hg38)
End
57699200/59621839 (Hg38)
Orient
-
Location type
Intronic
Target gene
CLTC
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-99a-3p ; hsa-mir-615-3p ; hsa-mir-503-5p ; hsa-mir-484 ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-let-7e-5p ; hsa-mir-4326 ; hsa-mir-544a ; hsa-mir-543 ; hsa-mir-377-3p ; hsa-mir-381-3p ; hsa-mir-485-3p ; hsa-mir-539-3p ; hsa-mir-487a-3p ; hsa-mir-376a-5p ; hsa-mir-382-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-1236-3p ; hsa-mir-6758-3p ; hsa-mir-877-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-199a-5p ; hsa-mir-195-3p ; hsa-mir-574-3p
Nearest miRNA
hsa-mir-10226/Upstream/255685; hsa-mir-1250/Downstream/219427;
Nearest TSS
ENST00000595228/Upstream/1896; ENST00000585198/Downstream/25807;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1920, chr17-CpG: 28/Downstream/85554
Upstream sequence
AAATAACAAAATGGACATTTTTTTTTGATCAATCCAAGTTTAGTTGCTGTGGTTGCTTTTGTTAAAGTGGGGTGGCAAATGAATGTGGAGAGTTGAGGGG
Downstream sequence
TGCTGTTCTTAAGTGTGAGGGGAAAACGCGGGCTTATTTTCATATTAAACTGCATCTGAAATATCTTTCTGCAGACAAATGTTTATAAACCACACAGAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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