Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene398258443955644239673137396737563967749439643034396450823965951039661512396861663968801539656305396581503968107539682673396505513965170439669614396707053964731239648033396534153965389339666874396670233967073439670883396881543968830339691143
Basic Information
VIS ID
TVIS44014980
Fusion event
HTLV-1-IGSF5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
41063070/39691143 (Hg38)
End
41063070/39691143 (Hg38)
Orient
+
Location type
Intronic
Target gene
IGSF5
Nearest miRNA
hsa-let-7c/Upstream/244074; hsa-mir-3197/Downstream/521209;
Nearest TSS
ENST00000624081/Upstream/33261; ENST00000419826/Downstream/36612;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/78076, chr21-CpG: 18/Downstream/453167
Nearby gene
B3GALT5(+28254) ;
Upstream sequence
catcatgcagaatagtttcactgccttaaaaatcttctgtgctctgcccatttatccttctctctcttctggcccctggtaacaactgatttttttaata
Downstream sequence
gtctccatagtttgccttttccagaatgtcatatggttgaaatcatactgtatgcagcctcttcagattggcttttttcacttagaaatgtgcatttaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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