Basic Information
VIS ID
TVIS44014982
Fusion event
HTLV-1-BOD1L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
13575820/13574196 (Hg38)
End
13575820/13574196 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
BOD1L1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-12113/Upstream/1790948; hsa-mir-12115/Downstream/53669;
Nearest TSS
ENST00000502981/Upstream/26395; ENST00000510907/Downstream/4005;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/26198, chr4-CpG: 47/Downstream/53425
Upstream sequence
agacagaaggttctgaaagtcgaactagaatcaagagtagaagccacagggaggccggcttctactgaacacaagtcagagaatgctaaggaggatgtgg
Downstream sequence
ctttccctgccactgaggtccatgcaaaagcaggaagaccctttcagaggagctgcaggtgcagtgactcaggcactgactggctattggtactacatga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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