Basic Information
VIS ID
TVIS44015028
Fusion event
HTLV-1-CLSTN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
139789655/140070813 (Hg38)
End
139789655/140070813 (Hg38)
Orient
-
Location type
Intronic
Target gene
CLSTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-3180-5p ; hsa-mir-3607-3p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-10b-3p ; hsa-mir-1343-5p ; hsa-mir-145-3p ; hsa-mir-1914-5p ; hsa-mir-3150a-3p ; hsa-mir-3175 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-5703 ; hsa-mir-6763-5p ; hsa-mir-6825-5p ; hsa-mir-6878-5p ; hsa-mir-7152-5p ; hsa-mir-939-5p
Nearest miRNA
hsa-let-7g/Upstream/5632907; hsa-mir-1224/Downstream/11495063;
Nearest TSS
ENST00000440867/Upstream/135626; ENST00000286349/Downstream/383918;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/134540, chr3-CpG: 37/Downstream/611804
Upstream sequence
caaaatgatactatggctcattcagaagagggattggcagtctgtggcttgctcaaatccagcccactgctgtttttgtaaataaaattttattagaaca
Downstream sequence
cagccactatcatttggttatgtatggtctgtggctgttttccagctacaaaggcagagttgagtagttactacagagactgaatgggtcacaaaagtct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate