Basic Information
VIS ID
TVIS44015040
Fusion event
HTLV-1-BCKDHB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
80856639/80146922 (Hg38)
End
80856639/80146922 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCKDHB
miRNAs that regulate target gene
hsa-mir-1-3p
Nearest miRNA
hsa-mir-10398/Upstream/1607613; hsa-mir-1202/Downstream/10165820;
Nearest TSS
ENST00000381078/Upstream/19653; ENST00000468520/Downstream/56180;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/39953, chr6-CpG: 231/Downstream/1604494
Nearest cancer related gene
BCKDHB(OG, No orient, 0)
Upstream sequence
GTTAATTCTCCAAGGAGAATGTATTAATAAAATacatctagagagaaggaaggctgggaaatgtagtctttgttctgtgtggacatgtgctcagctaaag
Downstream sequence
ctctggggttctgttactgcgggagaaggggagaataaatactgggggacaattagcagtTGGCACTATGCTTACATACACACATACTTGCTACATTAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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