Basic Information
VIS ID
TVIS44015057
Fusion event
HTLV-1-chr1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
GRCh37/hg19
Start
226119272/225931572 (Hg38)
End
226119272/225931572 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/9430; hsa-mir-1182/Downstream/2010018;
Nearest TSS
ENST00000473358/Upstream/7232; ENST00000366814/Downstream/8529;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6720, chr1-CpG: 64/Downstream/7840
Nearby gene
LEFTY2(-5026) ;
Nearest cancer related gene
LEFTY2(TSG, -5026) ;
Upstream sequence
ctggaggctctgggggaggatccaccttcagactcattcaagtgttggcagaattcgacttccatgtgggtgtagatctgaggtcccctttccttgctgg
Downstream sequence
ctatcagctgggagtcagcccaccttttagaggccactcacattctctagctcatggcttccctcatcttcagaccagcaatggcagggcaagtccttct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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