Basic Information
VIS ID
TVIS44015059
Fusion event
HTLV-1-SBF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
10099827/10078280 (Hg38)
End
10099827/10078280 (Hg38)
Orient
+
Location type
Intronic
Target gene
SBF2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-210/Upstream/987901; hsa-let-7a-2/Downstream/429990;
Nearest TSS
ENST00000527297/Upstream/33674; ENST00000532735/Downstream/70912;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/319357, chr11-CpG: 76/Downstream/215452
Upstream sequence
ctagtgtaaactagttcaaccattgtggaagacagtgtggtgactcctcaaggatctagagctagtaataccatttgatccagtgatcccattactgggt
Downstream sequence
atatacccaaaggattatcaatcattctaatataaagacacatgaacacatatgtttactgtagcactgttcacaatagcaaagacttggaaccaaccca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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