Basic Information
VIS ID
TVIS44015067
Fusion event
HTLV-1-CDK8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.13
Reference genome
GRCh37/hg19
Start
26940865/26366728 (Hg38)
End
26940865/26366728 (Hg38)
Orient
-
Location type
Intronic
Target gene
CDK8
miRNAs that regulate target gene
hsa-mir-26a-5p ; hsa-mir-193b-3p ; hsa-mir-10a-5p ; hsa-mir-107 ; hsa-mir-195-5p ; hsa-mir-101-3p
Nearest miRNA
hsa-mir-2276/Upstream/2204224; hsa-mir-1267/Downstream/13297306;
Nearest TSS
ENST00000623511/Upstream/112589; ENST00000465820/Downstream/18483;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/111762, chr13-CpG: 160/Downstream/190703
Nearest cancer related gene
CDK8(OG, No orient, 0)
Upstream sequence
GTAGGTATGTGTTCTGAAGATTCCTCTCTGTTCCCAAATAGATGTGTGAATTTCTAAAATCAATTTCTATTCTAATTTCCAGTCTTTTCAGATCACAGAC
Downstream sequence
AGGCTTGTAATTCAGGTCAGTGTAGTTTAAGATGCCTATTTAATAAAAACATAGAAGTTGGGAAGATAGATTGCTAATTTTTAAAAATTCATTTAACATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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