Basic Information
VIS ID
TVIS44015073
Fusion event
HTLV-1-OCA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q12
Reference genome
GRCh37/hg19
Start
28041209/27796063 (Hg38)
End
28041209/27796063 (Hg38)
Orient
-
Location type
Intronic
Target gene
OCA2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-6515-5p ; hsa-mir-6869-5p ; hsa-mir-5706 ; hsa-mir-526b-5p ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-1268a/Upstream/1947238; hsa-mir-10393/Downstream/630428;
Nearest TSS
ENST00000557528/Upstream/20442; ENST00000565126/Downstream/303230;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/24554, chr15-CpG: 42/Downstream/9041
Upstream sequence
AAATCAATAGTTGTTCTCAAGCACATTGTTTTTGTGCTTTCAGCAGCATCATAATTGAGTTTGTTTTTAATGCTTGTGCACCACTACCAGCCTGGTTACG
Downstream sequence
TACTCCCAGAAGGGAAAAGAAGATGCTCCAGCCATCCACGGTTCTAGCAGGACCTCAGGTTCTGCTGATTCACACATCTACTCTCTGACTGGAGGAACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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