Basic Information
VIS ID
TVIS44015087
Fusion event
HTLV-1-ZBTB7C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45905218/48378847 (Hg38)
End
45905218/48378847 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/998282; hsa-mir-122/Downstream/291753;
Nearest TSS
ENST00000575820/Upstream/3222; ENST00000591412/Downstream/30445;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/216706, chr18-CpG: 262/Downstream/29235
Nearby gene
CTIF(+160209) ;
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
agaacagaatgctataaaatgaacattcagagaatagaaacaaaaattcttgtaaattaaaaatataataaatgaagtactcagtagggagttggaatat
Downstream sequence
aaaattgaggaactcttccagaaagtaaagcaaaagacagagatggaaaagaggagagaaaagTCAATAAaactagaggctaatataagtgttctgagca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate