Basic Information
VIS ID
TVIS44015104
Fusion event
HTLV-1-CGGBP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
88127212/88078062 (Hg38)
End
88127212/88078062 (Hg38)
Orient
+
Location type
Intronic
Target gene
CGGBP1
miRNAs that regulate target gene
hsa-mir-96-5p ; hsa-mir-4709-3p ; hsa-mir-6867-3p ; hsa-mir-520f-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-3667-3p ; hsa-mir-5088-3p ; hsa-mir-4661-3p ; hsa-mir-186-5p ; hsa-mir-3133
Nearest miRNA
hsa-let-7g/Upstream/851785; hsa-mir-12124/Downstream/8281902;
Nearest TSS
ENST00000440867/Upstream/18788; ENST00000623596/Downstream/8258;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/19202, chr3-CpG: 70/Downstream/71302
Upstream sequence
GTAAATAAAACTACTTCATAGGTTGAATTCCTTTGTGAAATGTTGTGAAATTTCTTTGTATTTAATATAAAACATGCTTAATATGCTAATTCTGGAATCC
Downstream sequence
CTATATTAGCAAGTATAATACTCTTTACATTTCAAACTATTGTGAATATCGGACTGATTTCTTTGTTAAACTAGTTAGTAGGGTTTTGATATATATTCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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