Basic Information
VIS ID
TVIS44015123
Fusion event
HTLV-1-EGFR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55163926/55096233 (Hg38)
End
55163926/55096233 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
EGFR
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-7-5p ; hsa-mir-145-5p ; hsa-mir-128-3p ; hsa-mir-146a-5p ; hsa-mir-21-5p ; hsa-mir-542-5p ; hsa-mir-128b ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-27a-3p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-let-7a-5p ; hsa-mir-301b-3p ; hsa-mir-574-3p ; hsa-mir-219a-5p ; hsa-mir-302b-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-2861 ; hsa-mir-132-3p ; hsa-mir-875-5p ; hsa-mir-7-1-3p ; hsa-mir-491-5p ; hsa-mir-27b-3p ; hsa-mir-27a-5p ; hsa-mir-125b-5p ; hsa-mir-3622b-5p ; hsa-mir-520b ; hsa-mir-520e ; hsa-mir-133a-5p ; hsa-mir-146b-5p ; hsa-mir-1-5p ; hsa-mir-137 ; hsa-mir-122-5p ; hsa-mir-200a-3p ; hsa-mir-135a-5p
Nearest miRNA
hsa-mir-1183/Upstream/10214433; hsa-mir-10399/Downstream/1859552;
Nearest TSS
ENST00000635602/Upstream/77082; ENST00000450046/Downstream/13490;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/75821, chr7-CpG: 120/Downstream/158236
Nearest cancer related gene
EGFR(OG, No orient, 0)
Upstream sequence
AAAGTGAAGATTCGATTTGAGGTGAGTTCAGCACAAAAGCGTATCCCAGGCCCTCTGGCTCCAACTGCAGCCCTTTCTACCTCATTCCCAGACCCCACCT
Downstream sequence
AAGCCTTTTCTCTTCAAAATCTTCTCAGGCACACTGATACACATACCTCAGATTTTTAATTCTCCGGTTGTGTTCACCAGGTGCTTGGTCATGATTAAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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