Basic Information
VIS ID
TVIS44015127
Fusion event
HTLV-1-ANGPT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
108441058/107428830 (Hg38)
End
108441058/107428830 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANGPT1
Nearest miRNA
hsa-mir-12123/Upstream/2944365; hsa-mir-10400/Downstream/5214663;
Nearest TSS
ENST00000518652/Upstream/92308; ENST00000520037/Downstream/66165;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/770467, chr8-CpG: 92/Downstream/653797
Upstream sequence
ATAGCCACAGCATCAGTAGCTAATTCACCTTTATGGGAATCCCATTTGTTATTTTGACCTCTTGGCTCATTCTCTAACCAAATTGGCAAAATTCCCAATC
Downstream sequence
CACCCAAAGGTATTATAAAAAGCATTCATCCTATTATTGTCTTCTCTTAAACCCTCAGGTAAAATGAAAGAAAAGTGATTCATTCAATATTGCCTTTCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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