Basic Information
VIS ID
TVIS44015128
Fusion event
HTLV-1-IQANK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
144854507/143772337 (Hg38)
End
144854507/143772337 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
IQANK1
Nearest miRNA
hsa-mir-1204/Upstream/39184; hsa-mir-10400/Downstream/40620;
Nearest TSS
ENST00000518652/Upstream/515; ENST00000534089/Downstream/16583;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/111, chr8-CpG: 21/Downstream/17479
Nearby gene
SCRIB(-18583) ;
Upstream sequence
AGCAAGGTgggcgccgtgggccgcgggccgccgcgcTGAGGGGCGCGGTCCAGGGCCCTCAGGGGCCTCCTTCCCCCAGGGGCAAGGCCTGGATCTTGCT
Downstream sequence
CGGGGGGCCCGTCTTGCAGGGCGCTTTCGGTCCGACGCCGCTGTACCGTGCAGCCTTTGGGGGCCACCTGGCAGCTGTGGAGGTGCTCCTGAAGCTCGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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