Basic Information
VIS ID
TVIS44015138
Fusion event
HTLV-1-TDRD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
179632666/179663531 (Hg38)
End
179632666/179663531 (Hg38)
Orient
+
Location type
Intronic
Target gene
TDRD5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/985697; hsa-mir-1182/Downstream/140393;
Nearest TSS
ENST00000473358/Upstream/23580; ENST00000423879/Downstream/66686;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/71070, chr1-CpG: 197/Downstream/79281
Upstream sequence
CATAAGCCAGAAGTACTGGGTGCTCAGGAAAAAAATACTGGCACAAACAGGACTCAAAAGGTAAATGTCTAATGCAGGTTATTGGGACAGGTTTGCATAA
Downstream sequence
GGAAGTCCTTTCATTTTTAGAAAGCAAAAttgtctcaatttacatattttgatattgcctgtctcttaacagcttgctgtagctgttactgttgatgata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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