Basic Information
VIS ID
TVIS44015139
Fusion event
HTLV-1-PDE6C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
95397511/93637754 (Hg38)
End
95397511/93637754 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
PDE6C
Nearest miRNA
hsa-mir-107/Upstream/4044927; hsa-mir-1287/Downstream/2426561;
Nearest TSS
ENST00000439456/Upstream/25166; ENST00000475427/Downstream/24302;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36124, chr10-CpG: 33/Downstream/64649
Upstream sequence
gttaagattctaactctgtgttaaaacttttcatcatttgatctattttgactattttcccctgtattttcataaatgtattgatgtgtattattttaag
Downstream sequence
gtacccatcttaataccagaatcacctgtagatctgattctactgtttatttttacacctgggttctagtcatttgatcctgttttaaagcatgccttat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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