Basic Information
VIS ID
TVIS44015148
Fusion event
HTLV-1-XPC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
14188547/14147047 (Hg38)
End
14188547/14147047 (Hg38)
Orient
-
Location type
Intronic
Target gene
XPC
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-25-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-1184 ; hsa-mir-1306-5p ; hsa-mir-3065-3p ; hsa-mir-3135b ; hsa-mir-3649 ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4446-3p ; hsa-mir-4492 ; hsa-mir-4498 ; hsa-mir-483-5p ; hsa-mir-492 ; hsa-mir-5001-5p ; hsa-mir-505-5p ; hsa-mir-5193 ; hsa-mir-762 ; hsa-mir-331-3p ; hsa-mir-4453 ; hsa-mir-4538 ; hsa-mir-4732-3p ; hsa-mir-4750-3p ; hsa-mir-4757-5p ; hsa-mir-5196-3p ; hsa-mir-6744-3p ; hsa-mir-6801-3p ; hsa-mir-6810-3p ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-6878-3p
Nearest miRNA
hsa-mir-12127/Upstream/3752485; hsa-let-7g/Downstream/1349192;
Nearest TSS
ENST00000440867/Upstream/1629; ENST00000626655/Downstream/1239;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/21548, chr3-CpG: 75/Downstream/31168
Upstream sequence
ACTGGGAACACTGGAAGGCGGAAGGGTGCACCAAATGCAGGACACTTGGCCCTCCCTATGTGTTCAGCGCCAAATCAGACCCATGGCATTGCTCATGTGG
Downstream sequence
ACAGTAGAAACGGGGACACTGGGACAGGGCTTGGGGCAGAAGAGCCAGCTGAGGCCTCACTCCAGGGACACCTTTCCCAACAAGGTAAAAACAAGCGGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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