Basic Information
VIS ID
TVIS44015172
Fusion event
HTLV-1-TLL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
166883060/165961908 (Hg38)
End
166883060/165961908 (Hg38)
Orient
-
Location type
Intronic
Target gene
TLL1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6869-5p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-3924 ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4773
Nearest miRNA
hsa-mir-12113/Upstream/575571; hsa-mir-1305/Downstream/5224276;
Nearest TSS
ENST00000502981/Upstream/86950; ENST00000503003/Downstream/564211;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/87719, chr4-CpG: 27/Downstream/2356490
Upstream sequence
agaaattaactcaagatggattaaagaattaagtgtaaacacaatttaaaaatatatatgatcatctcagtagatgcagaaaaagcttttgatataatcc
Downstream sequence
tgcctcccttcaggataaaaaccctcaaaaactagacatcgaagaaacatgacctcaaaatacaaaaatcctggaagaaaaactaagaaatgttcttctt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate