Basic Information
VIS ID
TVIS44015178
Fusion event
HTLV-1-UVRAG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
75809548/76098504 (Hg38)
End
75809548/76098504 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
UVRAG
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-32-5p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-33a-5p ; hsa-mir-301a-3p ; hsa-mir-205-5p ; hsa-mir-183-5p ; hsa-mir-203a-5p
Nearest miRNA
hsa-mir-10392/Upstream/763318; hsa-let-7a-2/Downstream/3303518;
Nearest TSS
ENST00000527297/Upstream/118444; ENST00000525183/Downstream/17396;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/282623, chr11-CpG: 79/Downstream/65889
Nearest cancer related gene
UVRAG(TSG, No orient, 0)
Upstream sequence
caaggtcatacagagagtaactcgcaaacctagatgccaaccaaagaccctttcattttgttgttccttctcctgtaccaTCTCATATATTTTAAAATGG
Downstream sequence
CTTTTTATTAGATTGTTTTTCAGTCAAGAATTTTTGGAGTTAGCTAGGAAGTTAATGTGTAAGTGGCAGTTTGAAGATAGAAGACCACATCATTGTTTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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