Basic Information
VIS ID
TVIS44015180
Fusion event
HTLV-1-AQP4-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
24474107/26894143 (Hg38)
End
24474107/26894143 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
AQP4-AS1
Nearest miRNA
hsa-mir-1-2/Upstream/302608; hsa-mir-122/Downstream/3404767;
Nearest TSS
ENST00000575820/Upstream/28325; ENST00000631265/Downstream/15678;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/30697, chr18-CpG: 54/Downstream/290844
Upstream sequence
CTGGTAACAATTCCAAATTTGGAATGAAAAAGTTACTCTTTGTTTAGCGTTCGAGTTGGGAGTTTGCCCTGCAAGAGACAGTCAACCACTGACTTCAGTC
Downstream sequence
GAACGTACTTGGAAAGGGAAGAACTTAAACCAGCCATGAACAGAAGAAAGCCAGGTTTTCTGGAAACATCGCCAAAACCCAGCAATTTCTCAGAATTTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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