Basic Information
VIS ID
TVIS44015205
Fusion event
HTLV-1-MEF2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
100207117/99666912 (Hg38)
End
100207117/99666912 (Hg38)
Orient
+
Location type
Intronic
Target gene
MEF2A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-132-3p ; hsa-mir-21-5p ; hsa-mir-30a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-10393/Upstream/882410; hsa-mir-1302-10/Downstream/2293547;
Nearest TSS
ENST00000557528/Upstream/100429; ENST00000561125/Downstream/39683;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/100052, chr15-CpG: 84/Downstream/65784
Upstream sequence
CACCAGCTTGAATTTCATTTTAGATCTTAATAGCTTCCGACAGAAAGGAAGGTTGTGGGATTTGCTGTTTTAGACAGTTAACATTCTTAATGCTGCAATA
Downstream sequence
TAAATAACAATTTATGAATTACCACAAGAAGATTTTGAAGATGAGTATTGAAAGGCCACAGGCCCTGTCTTGTCATATTTCATCGATACTTGATATTATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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