Basic Information
VIS ID
TVIS44015208
Fusion event
HTLV-1-DNM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10876584/10765908 (Hg38)
End
10876584/10765908 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
DNM2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-130a-3p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-mir-6875-5p ; hsa-mir-6809-5p ; hsa-mir-765 ; hsa-mir-711 ; hsa-mir-4784 ; hsa-mir-4708-3p ; hsa-mir-3150b-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4761-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125
Nearest miRNA
hsa-mir-1181/Upstream/47405; hsa-let-7e/Downstream/14346;
Nearest TSS
ENST00000633603/Upstream/2809; ENST00000587991/Downstream/2645;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/47244, chr19-CpG: 70/Downstream/69932
Upstream sequence
TTGGGAAAGGCAGATCTCCTCTCCTTGCCTTCAGGGCCAGCCTCGTCATTGTGTTCTTTGCTGGGGGAACGGTGAGAAGATCCAGGGCAGAGCCCCAGTG
Downstream sequence
TGCAAAGCACTGGGACCCTAGCCCAGCCCCTGAGGGTTCCCTGAGACTAACAGCTGAGCCGTGTTTGTGCTCCTGATGGGATTTGATCGCAGTCATATGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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