Basic Information
VIS ID
TVIS44015216
Fusion event
HTLV-1-EDEM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p26.1
Reference genome
GRCh37/hg19
Start
5231070/5189385 (Hg38)
End
5231070/5189385 (Hg38)
Orient
+
Location type
Intronic
Target gene
EDEM1
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-335-5p ; hsa-mir-32-5p ; hsa-mir-125b-5p ; hsa-mir-100-5p ; hsa-mir-96-5p ; hsa-mir-581 ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-4330 ; hsa-mir-4793-3p ; hsa-mir-6715a-3p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-491-3p ; hsa-mir-1468-3p ; hsa-mir-1301-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-548aj-5p ; hsa-mir-4660 ; hsa-mir-5047 ; hsa-mir-548aw ; hsa-mir-10b-3p ; hsa-mir-3922-5p ; hsa-mir-6885-3p ; hsa-mir-2052 ; hsa-mir-5692a ; hsa-mir-548c-3p ; hsa-mir-4261 ; hsa-mir-549a ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-888-5p
Nearest miRNA
hsa-let-7g/Downstream/60792;
Nearest TSS
ENST00000440867/Upstream/1036; ENST00000492751/Downstream/5721;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/880, chr3-CpG: 71/Downstream/1671751
Upstream sequence
CACCTGGAGGAAAGCAGTGGAGTCCAGTCCTTAGGTTCTGATAAGGAAGCCTATAGACTAAACGGAGTTGGGTTTTTAAAATGGTGTGGTTATTTACACA
Downstream sequence
TTTATGTTTTAAATTGCAGTTTGAGAGCATGATTTCTACCGAAGCAAGGGGACATCCCAAGCTAAATTCAAAGGACTGAGCCTTTTCAAAATTCTAGGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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