Basic Information
VIS ID
TVIS44015219
Fusion event
HTLV-1-KALRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
124056545/124337698 (Hg38)
End
124056545/124337698 (Hg38)
Orient
-
Location type
Intronic
Target gene
KALRN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-186-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-8485 ; hsa-mir-1197 ; hsa-mir-329-3p ; hsa-mir-362-3p ; hsa-mir-6851-3p ; hsa-mir-5000-5p
Nearest miRNA
hsa-let-7g/Upstream/204673; hsa-mir-12124/Downstream/36634;
Nearest TSS
ENST00000440867/Upstream/3271; ENST00000522553/Downstream/46865;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/68599, chr3-CpG: 50/Downstream/246984
Upstream sequence
attttctttttttgttgtgtctccgacagggtttggtatcaggatgatgctggccttataaaatgagttagggaggagtccctcttcttctattgtttgg
Downstream sequence
aatagtttcagaaggaatgataccagctcctctttgtatctctgttagaattcggctgtgaatccatctggtcctggacgtttttttgttggtagactat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate