Basic Information
VIS ID
TVIS44015235
Fusion event
HTLV-1-MTRNR2L10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
55208199/55181766 (Hg38)
End
55208199/55181766 (Hg38)
Orient
-
Location type
UTR3
Target gene
MTRNR2L10
miRNAs that regulate target gene
hsa-mir-653-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-508-3p ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-5186 ; hsa-mir-550b-3p ; hsa-mir-517-5p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-8076 ; hsa-mir-6755-5p ; hsa-mir-6841-5p ; hsa-mir-3159 ; hsa-mir-5684 ; hsa-mir-652-5p ; hsa-mir-6771-3p ; hsa-mir-4677-5p ; hsa-mir-1229-5p ; hsa-mir-1225-5p ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-26b-3p ; hsa-mir-1266-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-640 ; hsa-mir-3151-3p ; hsa-mir-1265 ; hsa-mir-219b-5p ; hsa-mir-2392 ; hsa-mir-6512-5p ; hsa-mir-651-5p
Nearest miRNA
hsa-let-7f-2/Upstream/1624492; hsa-mir-105-1/Downstream/269729;
Nearest TSS
ENST00000429181/Upstream/20456; ENST00000289619/Downstream/1154;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/20192, chrX-CpG: 38/Downstream/306881
Upstream sequence
GACTCTAGAATAGGATTGCGCTGTTATCCCTAGGGTAACTTACTCCGTTGATCAAATTATCGGGTCAATATATATTAACTTGCTTAGGCTAGTGCAGTCT
Downstream sequence
TAGTTTAGGTTGCTCGGAGGTTGAATTATGCTCTGAGGTCACCCCAACCAAAAATTTTAATGCAGGGATAGTAGGCTAGGGCCTGTAGGCTTAAGTTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate