Basic Information
VIS ID
TVIS44015236
Fusion event
HTLV-1-PRDM16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
3226278/3309714 (Hg38)
End
3226278/3309714 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
PRDM16
miRNAs that regulate target gene
hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-96-5p ; hsa-mir-615-3p ; hsa-mir-346 ; hsa-mir-221-3p ; hsa-mir-101-3p
Nearest miRNA
hsa-mir-12136/Upstream/181679; hsa-mir-101-1/Downstream/250981;
Nearest TSS
ENST00000473358/Upstream/65582; ENST00000606170/Downstream/382;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/21825, chr1-CpG: 24/Downstream/13637
Nearest cancer related gene
PRDM16(OG, No orient, 0)
Upstream sequence
GAAGGTGCTGGAGCGGGGTAAGCTGAGCTGTCCTTGTCCTGGTTGTTTTCATATTCTGACACTTCCCGCATCCCTGCAGGACCAGCTCACCTTGGGAAAG
Downstream sequence
GGGCCGAGACTTGAACACATGACTGTGACTCCAGAGGCCAGGGCTGCCCTGGGCTAGGAGCAGAGGGCTACAGCCACTGTCAGAGGGAGGACCTGAGAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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