Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene128902984128809623128875224128808916128814390128824267128828200128853341128856539128843972128846859128814981128817790128830468128833211128821999128824151128840680128842068128838872128840219128835254128836254128819001128819400128821638128821655128855950
Basic Information
VIS ID
TVIS44015271
Fusion event
HTLV-1-JADE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q28.2
Reference genome
GRCh37/hg19
Start
129777105/128855950 (Hg38)
End
129777105/128855950 (Hg38)
Orient
+
Location type
Intronic
Target gene
JADE1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-145-5p ; hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-342-5p ; hsa-mir-324-3p ; hsa-mir-3934-3p ; hsa-mir-4427 ; hsa-mir-219b-3p ; hsa-mir-4680-3p ; hsa-mir-5010-3p ; hsa-mir-5187-3p ; hsa-mir-6854-5p ; hsa-mir-8068 ; hsa-mir-219a-2-3p
Nearest miRNA
hsa-mir-12113/Upstream/3348643; hsa-mir-1305/Downstream/14487510;
Nearest TSS
ENST00000502981/Upstream/24517; ENST00000502360/Downstream/80754;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/43120, chr4-CpG: 56/Downstream/237244
Upstream sequence
ctctgtcgcccaggctggagtgcagtgagctggatcatggctcactgcagccttgacctgctgggctcaagtgatcctcccacctcagccttttgagtag
Downstream sequence
ctgagattataggcatgtgctaccaggcccagcttattttttattttttgtagtgaggggatctcactttgttgacctggctggtctcaaactcctggga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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