Basic Information
VIS ID
TVIS44015299
Fusion event
HTLV-1-VIM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
17276984/17234985 (Hg38)
End
17276984/17234985 (Hg38)
Orient
-
Location type
Intronic
Target gene
VIM
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-17-3p ; hsa-mir-30c-5p ; hsa-mir-9-5p ; hsa-mir-138-5p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-3605-3p ; hsa-mir-378a-3p ; hsa-mir-506-3p ; hsa-mir-204-5p ; hsa-mir-875-3p ; hsa-mir-548e-5p ; hsa-mir-3148 ; hsa-mir-4328 ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-5681b ; hsa-mir-6124 ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-4272 ; hsa-mir-320a ; hsa-mir-129-5p ; hsa-mir-134-5p
Nearest miRNA
hsa-mir-1265/Upstream/2798324; hsa-mir-107/Downstream/610122;
Nearest TSS
ENST00000439456/Upstream/152; ENST00000457649/Downstream/92124;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/4367, chr10-CpG: 103/Downstream/218423
Nearest cancer related gene
VIM(TSG, No orient, 0)
Upstream sequence
TACCTGAACAAAATGTTGAGTGAGTAAAAATGTATATCATAATGCAAAGAAAATGAGTTATCAAGACAGACTCAAAAGGGACTTCATGGAACTCTTGAAG
Downstream sequence
GTTTTAGCTTGCCTATATCATTGCTTCTAATATGAAGGACTTGGTACTCGCATTCTCCACCTAAAATTAGAGTGGTCGCCATTTGCCGCTAATGGAAATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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