Basic Information
VIS ID
TVIS44015313
Fusion event
HTLV-1-GGA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73232776/75236681 (Hg38)
End
73232776/75236681 (Hg38)
Orient
-
Location type
UTR3
Target gene
GGA3
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-423-5p ; hsa-mir-615-3p ; hsa-mir-23a-3p ; hsa-mir-222-5p ; hsa-mir-6735-3p ; hsa-mir-214-5p ; hsa-mir-98-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936 ; hsa-mir-196b-5p ; hsa-mir-1265 ; hsa-mir-2392 ; hsa-mir-451b ; hsa-mir-302c-5p ; hsa-mir-3691-3p ; hsa-mir-3143 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-10226/Upstream/487982; hsa-mir-1250/Downstream/169388;
Nearest TSS
ENST00000595228/Upstream/1928; ENST00000577767/Downstream/2304;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/30654, chr17-CpG: 89/Downstream/24418
Upstream sequence
ACTAGGAAGATTCCAAGTACAGTGAAAATGGTTTTATTTAACATGCAGCAAAACAAGGGCAGCAGAGCTGGGATATCCAGTACAGCCATTTGCCACGAAG
Downstream sequence
CACTGACCTCAACAGTAACGAGTAACACTCAAATAACTGTAATGTCTAGAGCATAACACAAAGTTCCATTTCCACATAGTAATTCCACAGACATTCCCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate