Basic Information
VIS ID
TVIS44015315
Fusion event
HTLV-1-LRRTM4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
77323745/77096619 (Hg38)
End
77323745/77096619 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRRTM4
miRNAs that regulate target gene
hsa-mir-1305 ; hsa-mir-6868-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/2005705; hsa-mir-10b/Downstream/2552675;
Nearest TSS
ENST00000437798/Upstream/110654; ENST00000438443/Downstream/425591;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1385606, chr2-CpG: 32/Downstream/1896447
Upstream sequence
aaaatgtctatattaaaagtcgagaataaaagacaaaatgagagttaaataatgtctgattatgacatgatataaaagtaaaaagtgataaaatctagaa
Downstream sequence
tactgtacattttctgaattgatttgagaatatagagaatagataaaggtattgtgaaatcagtatgaatattagcatgttaatagtaactaaaagtact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate