Basic Information
VIS ID
TVIS44015320
Fusion event
HTLV-1-ANXA6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
150532766/151153205 (Hg38)
End
150532766/151153205 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANXA6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-877-3p ; hsa-mir-324-5p ; hsa-mir-3138 ; hsa-mir-3689d ; hsa-mir-4520-3p ; hsa-mir-6134 ; hsa-mir-6851-5p ; hsa-mir-7847-3p ; hsa-mir-8071 ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3191-5p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-4487 ; hsa-mir-4633-3p ; hsa-mir-484 ; hsa-mir-516b-5p ; hsa-mir-518c-5p ; hsa-mir-593-3p ; hsa-mir-6500-5p ; hsa-mir-6764-3p ; hsa-mir-6824-3p ; hsa-mir-6874-5p
Nearest miRNA
hsa-mir-10397/Upstream/1420315; hsa-mir-103a-1/Downstream/368882;
Nearest TSS
ENST00000502646/Upstream/1726; ENST00000523466/Downstream/4542;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/71902, chr5-CpG: 40/Downstream/4325
Upstream sequence
CTCAGCAGTCGAGGCCATTGGTTCTCCTTACTGACTTCTTTGCCATCACCACTTTCCTCTTTGCCCTGTCTTCCCTGCTAAACCAGGAACGCCTTCCACC
Downstream sequence
AACATTTTTAATCCAGCTTTCCAGAATCTATACcagtgcttttcaattctagcttcactaacagaacctggggaatttttcaaaactaccaaagatttaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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