Basic Information
VIS ID
TVIS44015325
Fusion event
HTLV-1-SHISAL2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
53104191/52638519 (Hg38)
End
53104191/52638519 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
SHISAL2A
Nearest miRNA
hsa-mir-12136/Upstream/802117; hsa-mir-101-1/Downstream/1415560;
Nearest TSS
ENST00000473358/Upstream/4926; ENST00000545132/Downstream/59549;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4888, chr1-CpG: 49/Downstream/59497
Upstream sequence
TAATTAAAGTAACTAAAGAACTAAAAAGCCCTACATACTCAATGTAAAAAATGTGAAAAGGACAAGAGAAATGAAAAGAGAAAGAAGTCATGAGTAATCC
Downstream sequence
AGtgtctaagcttggattcaccaggagactctgagatgaggatttgatggcaagtagtttatgtggaaagtgatcccaaaaatcactggtagaggataag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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