Basic Information
VIS ID
TVIS44015343
Fusion event
HTLV-1-MYO1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
192141113/191276387 (Hg38)
End
192141113/191276387 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYO1B
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-378a-5p ; hsa-mir-363-3p ; hsa-mir-4703-3p ; hsa-mir-145-3p ; hsa-mir-6780b-3p ; hsa-mir-4698 ; hsa-mir-7852-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-3646 ; hsa-mir-561-3p ; hsa-mir-3662
Nearest miRNA
hsa-mir-10b/Upstream/2143276; hsa-mir-1244-1/Downstream/15506847;
Nearest TSS
ENST00000437798/Upstream/12814; ENST00000496992/Downstream/498;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/30173, chr2-CpG: 88/Downstream/401460
Upstream sequence
GTTCTTTCACATCAAATGCAAAACATTTTTAAgtaaccatagcaagtttcataatctctgagcttcaattttcttatcttaaagtgggaatgacaatacc
Downstream sequence
tacctcatagagttattgtgagggttcaattaatgtaaagttcttggtatagtgtctgatatgtggcaagtaaacaacaaatgttagcagcatcattTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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