Basic Information
VIS ID
TVIS44015345
Fusion event
HTLV-1-chr21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
32062957/30690639 (Hg38)
End
32062957/30690639 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/315261; hsa-mir-3197/Downstream/2860023;
Nearest TSS
ENST00000624081/Upstream/47775; ENST00000433071/Downstream/28138;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/750851, chr21-CpG: 24/Downstream/561189
Nearby gene
KRTAP21-3(-27886) ;
Upstream sequence
TATGTCATTCAAGAACACCAAAACTATTTATAAATACATTTGGAGAAAATGTTTCCCTTTAAATTTAGCATATCTGTTTCTCCTGAAAATACCCACAGGG
Downstream sequence
ACACAGTCTTTTATTTTGAATCAACTTCCAAAAGTGCTGCATCTCCTTGTCATGCAATTGTAGTGTCAGGTCTCCACAGGTAATTATATCTGCATCAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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