Basic Information
VIS ID
TVIS44015350
Fusion event
HTLV-1-ATP10B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
160130692/160703685 (Hg38)
End
160130692/160703685 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP10B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10397/Upstream/218235; hsa-mir-103a-1/Downstream/7462160;
Nearest TSS
ENST00000502646/Upstream/18300; ENST00000518888/Downstream/148469;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/281579, chr5-CpG: 68/Downstream/844001
Upstream sequence
cctgcctcagccttctgggtagctggggctacaggcacctgggtaatttttgaatttttagtaaaaatgaggtttcatcatgttggccaggttggtcttg
Downstream sequence
aacgcctgacctcaggtgatccatcagccttggcctcccatagtgctgggattacaggtgtgagtcactgtgcctggcttgtcttgatgttatggctgtt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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