Basic Information
VIS ID
TVIS44015365
Fusion event
HTLV-1-NUP88 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5301763/5398443 (Hg38)
End
5301763/5398443 (Hg38)
Orient
+
Location type
Intronic
Target gene
NUP88
Nearest miRNA
hsa-mir-1253/Upstream/428293; hsa-mir-10226/Downstream/1256997;
Nearest TSS
ENST00000595228/Upstream/3464; ENST00000575711/Downstream/1190;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/115596, chr17-CpG: 95/Downstream/20744
Upstream sequence
ctgtggcacgatatcggctcactgcaactccgcctcctgggttcaagcgattctcctgcctcagcctccagagtagcagggattataggcgcacaccacc
Downstream sequence
atgcctggctaatttttgtatttttagtagagacggggtttcgccatgttgactagactgttcgcaaactcccctgacctcgggtgatccacaagccttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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