Basic Information
VIS ID
TVIS44015374
Fusion event
HTLV-1-TARS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33457875/33457770 (Hg38)
End
33457875/33457770 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
TARS
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-191-5p ; hsa-let-7a-5p ; hsa-mir-6780a-3p ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-4786-3p ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-4267 ; hsa-mir-3065-3p ; hsa-mir-500b-3p ; hsa-mir-6858-3p ; hsa-mir-6871-3p
Nearest miRNA
hsa-mir-10397/Upstream/1063295; hsa-mir-103a-1/Downstream/2690122;
Nearest TSS
ENST00000502646/Upstream/1736; ENST00000509410/Downstream/3238;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/16511, chr5-CpG: 25/Downstream/44179
Upstream sequence
GTATAACAGCTTCTCATagagctgggagaactatggaaaccctctagtttcactgactcatttaaaatgtggaaacagagtcccacaaagattaacctac
Downstream sequence
ttgttgcccaaggtttagcagcATGTCGCACATGGATCCTGTGCTATCATTTCCTCTACCCATTATCTCTGTTACTGCTGAATGTCCTCTAAACTGGAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate