Basic Information
VIS ID
TVIS44015385
Fusion event
HTLV-1-TBC1D8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
101744259/101127797 (Hg38)
End
101744259/101127797 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
TBC1D8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-488-3p ; hsa-mir-4635 ; hsa-mir-145-3p ; hsa-mir-7161-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-4666a-3p ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-7849-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/4329444; hsa-mir-10b/Downstream/181653;
Nearest TSS
ENST00000437798/Upstream/17834; ENST00000610202/Downstream/23456;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/125601, chr2-CpG: 147/Downstream/22783
Upstream sequence
agcCTTGTTGACCTTTTAGCACCATGagaaatcagagagatgagtccaacctcctcattggataggtgaggaacctgagcctggaggaagttggtggagg
Downstream sequence
atgtgagggtcacaGCTCCTGAGTCCTGCTCGGAGCTCTTCCCATTGTTGCTGCTCTACCCTTCGGGAGCCTAGGACCACACACACAGCTTACTTAATGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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