Basic Information
VIS ID
TVIS44015388
Fusion event
HTLV-1-TBC1D14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
6955926/6954199 (Hg38)
End
6955926/6954199 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
TBC1D14
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-320a ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-149-5p ; hsa-mir-24-3p ; hsa-mir-4252 ; hsa-mir-4268 ; hsa-mir-4284 ; hsa-mir-4448 ; hsa-mir-6772-3p ; hsa-mir-892b
Nearest miRNA
hsa-mir-378d-1/Upstream/1030871; hsa-mir-12113/Downstream/356251;
Nearest TSS
ENST00000502981/Upstream/43951; ENST00000467966/Downstream/21;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30335, chr4-CpG: 94/Downstream/32379
Upstream sequence
GGGAGGCCCGCCCTGCCGCCCCCGCCTTTCCGCCGGCCTGCTGGGTCCAGCTTGCCTTCATCTGGCAGACGCGAGGGGCGGGGCTCCGAGTGCACCCATG
Downstream sequence
GAGTTTCCCCGGGACTGTGGCTCTGGCGTGCCAGGAATGCGGCACGGGGAGAGTCCGTGCTTCTGCAGCCGGCCCCTCGGAGCTGCGAGGTCACAGTAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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